منابع مشابه
assessment of the effect of honey as a topical therapy for intra oral wound healing in rat.
چکیده ندارد.
15 صفحه اولMajor phase I biotransformation pathways of Trichostatin a in rat hepatocytes and in rat and human liver microsomes.
Phase I biotransformation of Trichostatin A (TSA), a histone deacetylase inhibitor with promising antifibrotic and antitumoral properties, was investigated in rat and human liver microsomes and in suspensions of rat hepatocytes. TSA (50 micro M) was readily and completely metabolized by rat hepatocytes in suspension (2 x 10(6) cells/ml), whereafter its phase I metabolites were separated by high...
متن کاملIn vitro biotransformation of sildenafil (Viagra) in the male rat: the role of CYP2C11.
To assess the suitability of the male rat model for human studies on sildenafil metabolism, we examined the biotransformation of sildenafil in male rat liver microsomes and identified the role of specific cytochrome P450s (P450) using inhibitory antibodies and cDNA-expressed P450s. Rates of formation of the major circulating metabolite of sildenafil, UK-103,320, were 11-fold greater in the male...
متن کاملKinetics of Cyclophosphamide Biotransformation in
with its ring-opened tautomer, aldophosph$mide. it is generally agreed that, as such, 4-hydroxycyclopho$phamide-aldophos phamide is without significant antitumor aCtivity and that it can undergo 2 fates: conversion to relatively floncytotoxic metab olites, namely, 4-ketocyclophosphamide,; carboxyphospham ide, and alcophosphamide; and conversioVito cytotoxic metab olites, namely, acrolein, phosp...
متن کاملBiotransformation of Hydrocortisone by Neurospora crassa
The ability of Neurospora crassa FGSC 4335 in the biotransformation of hydrocortisone was investigated. The microorganism produced two major metabolites after incubation with the substrate for seven days. Each microbial product was purified chromatographically and identified on the basis of spectral data. The products were identified as 11?,17?,20?,21-tetrahydroxypregn-4-en-3-one (II) and 11?-h...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1972
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.20.1587